For the residents and visitors of Boquete Panama
The answer now is no; however sometime in Jun 2010 they began an expeansion upgrade of David airport which will allow larger planes to land there leading to direct flights to and from the U.S. and was projected to be completed in 20 months -- so figure sometime mid 2012 at the earliest.
Apparently the problem is that the airport does not comply with the USA safety regulations. The fuel tanks are too close to the air traffic control tower.
This is an old post so I'm wondering if there is anything new on this front? Is it possible to fly into David from anywhere but Panama City? AirPanama shows a route from Costa Rica but doesn't seem to be available for booking?