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Piper longum [pipali]
Currently chemotherapy is limited mostly to DNA-toxic drugs that are associated with severe side effects due to non-specific (don’t distinguish between diseased and healthy cells) "shotgun" approach and are designed to kill ALL fast-replicating cells – the good as well as the bad.
Cancer treatment is excruciatingly painful and for the families and friends who have to helplessly witness it. And while we hear that progress has been made in the “survival” rates of cancer since the 1960’s, at what price? More than 62% of children who have “survived” cancer treatment suffer from serious life-long disabilities and health problems – many times leading to early death. The treatment itself, the resulting side-effects, and long-term affects are unacceptable.
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Alkylating agents are medicines that directly damage the DNA in every cell, with the concept that fast-growing cells, like cancer cells, will be prevented from multiplying.
But what happens to other vital cells in your body? All medicines have side effects.
Alkylating agents can cause long-term damage to the bone marrow. Your bone marrow produces white blood cells (leukocytes), red blood cells (erythrocytes), and platelets (thrombocytes).
Bone pain, anemia, organ swelling and lowered immunity are due to suppression of new bone marrow production.
Many chemotherapies have a life-long toxicity that can cause secondary cancers, heart and liver damage, brain damage or disabilities.
Dried ground pepper has been used since antiquity for both its flavor and as a traditional medicine. Black pepper is the world's most traded spice. It is one of the most common spices added to European cuisine and its descendants. The spiciness of black pepper is due to the chemical piperine.
A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell’s revved-up metabolism and skyrocketing levels of cellular stress. Just as a cancer cell depends on a hyperactive metabolism to fuel its rapid growth, it also depends on anti-oxidative enzymes to quench potentially toxic reactive oxygen species (ROS) generated by such high metabolic demand.
Scientists at the Broad Institute and Massachusetts General Hospital have discovered a novel compound that blocks this response to oxidative stress selectively in cancer cells but spares normal cells, with an effectiveness that surpassed a chemotherapy drug currently used to treat many forms of cancer.
The plant-based compound piperlongumine (PL), derived from the fruit of a pepper plant found in southern India and southeast Asia, appears to kill cancer cells by jamming the machinery that dissipates high oxidative stress and the resulting ROS.
“Cancer cells have a greater dependence on ROS biology than normal cells.The novelty of this compound piperlongumine was that it was able to recognize cancer cells from normal cells...It has a mode of action that targets something especially important to the cancer cell.”
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Dandelion and Root
Taraxacum Officinale is most commonly known as dandelion. Regarded as a regular garden weed, this detoxifying herb has long been used in traditional Chinese medicine, for ailments ranging from digestive disorders to complex disorders such as uterine, breast and lung tumours.
Traditional Middle Eastern remedies require dandelions for spleen and liver ailments, while Native Americans have harnessed their properties to cure indigestion, heartburn, and kidney disease.
Taraxacum Officinale extracts reduce levels of reactive oxygen species (ROS) and nitric oxide production (NO) and inhibit COX-2 expression, thus making dandelion extracts not only anti-carcinogenic, but anti-inflammatory, antiangiogenic [Angiogenesis means the growth of new blood vessels. If we can stop cancers from growing blood vessels we can slow the growth of the cancer or sometimes shrink it] and also antinociceptive [inhibits the sensation of pain].
Melanoma is the most prevalent form of cancer for the 25-29 North American age demographic. In this study, we show that dandelion root extract (DRE) specifically and effectively induces apoptosis in human melanoma cells without inducing toxicity in noncancerous cells.
Thirty patients are being recruited to take part in a study looking at the potentially cancer-killing abilities of dandelion root extract.
The phase one clinical study, as it's called, is part of the Dandelion Root Project, aimed at showcasing scientific evidence for the safe and effective use of dandelion root extract and other natural health products for cancer therapy.
According to researchers, test results done prior to the clinical trial showed that dandelion tea, containing dandelion root extract, killed cancer cells in a lab.
Dr. Siyaram Pandey is a professor of chemistry and biochemistry at the University of Windsor and is the principal research investigator on the project.
He said the dandelion extract has "good potential" to kill cancer cells.
30 patients to test dandelion's cancer-killing potential
Stress Relief In 1 Minute
Cranial Release Technique 2000+ migraines gone since 2005